Oxalate deposition in the renal allograft biopsy within 3 months after transplantation
M.L.H. Snijders, M.C. Clahsen-van Groningen, D.A. Hesselink, J.I. Roodnat
Chair(s): Drs. F.E. van Reekum & dr. M.C. Warlé
Wednesday 8 march 2017
18:18 - 18:30h
at Johan de Meesterzaal
Categories: Parallel - Klinisch
Parallel session: Parallelsessie VII - Klinisch 2 - Nazorg na orgaantransplantatie
Background and aims:
Deposition of calcium oxalate (CaOx) may impair both native and transplant renal function. We analyzed the role of CaOx in postoperative transplant dysfunction.
Methods:
We retrospectively analyzed all preimplantation renal biopsies (t0) for CaOx obtained in 2000-2001. Thereafter, we retrospectively investigated all for-cause renal allograft biopsies obtained within 3 months post-transplantation of patients transplanted in 2014-2015 for CaOx. Clinical data were collected. H&E stained slides were analyzed using polarized light.
Results:
A total of 106 t0 biopsies (56 living, 50 deceased donor) were available for analysis, 1 showed CaOx (0.94%) (living donor). 388 patients were transplanted in 2014 and 2015; 77 had DGF, 148 (38.4%) had at least one biopsy within the first 3 months after transplantation. Twenty-four (16%) patients showed CaOx in their biopsy. No diagnosis (ATN, rejection or other) prevailed in the CaOx. DGF was more frequent with CaOx (p=0.02). Significantly more patients with CaOx had been on dialysis before transplantation (p=0.023). Other clinical parameters investigated were not significantly different between the groups. In the CaOx population 3 grafts failed (12.5%) and 2 patients died (8.3%) versus 8 (6.5%) and 6 (4.8%) in controls (ns).
Conclusion:
One in 6 patients have CaOx in their renal allograft biopsy within 3 months after transplantation which can contribute to renal dysfunction. Prevalence was not significantly different between recipients of living or deceased donor kidney, but it prevailed significantly in patients that were on dialysis before transplantation. Patients with DGF significantly more often had CaOx.
